RP-HPLC METHOD DEVELOPMENT FOR THE SIMULTANEOUS DETERMINATION OF SIMVASTATIN AND EZETIMIBE
AbstractAbstract- A simple, sensitive and specific RP-HPLC method was developed and validated for the simvastatin and ezetimibe tablet. The mobile phase for these method, composed of ethanol: acetonitrile: orthophosphoric acid (65:30:5) was used at 0.1ml/mint. Flow rate, C18 hypersil column was used and isocratic elution best at 25◦c-5◦c.UV detector was used, detect at 245 for starting 10 min and 253 for 15-20 min. The all validation parameters were examined in acceptable range. This work is accepted with application of precise, accurate and simple. Determination of the different analytical parameters such as linearity, precision, accuracy, specificity, LOD and LOQ was done. The proposed method was applied successfully for simultaneously determination of Simvastatin and Ezetimibe. Keywords: Ezetimibe, Simvastatin, reverse phase high performance liquid chromatography, tablets.
How to Cite
Achla Vyas, A. N. R. N. (1). RP-HPLC METHOD DEVELOPMENT FOR THE SIMULTANEOUS DETERMINATION OF SIMVASTATIN AND EZETIMIBE. ACCENT JOURNAL OF ECONOMICS ECOLOGY & ENGINEERING ISSN: 2456-1037 INTERNATIONAL JOURNAL IF:7.98, ELJIF: 6.194(10/2018), Peer Reviewed and Refereed Journal, UGC APPROVED NO. 48767, 5(1). Retrieved from http://ajeee.co.in/index.php/ajeee/article/view/114